Patellofemoral osteoarthritis (PFOA) is a subtype of knee osteoarthritis, featuring high prevalence and heavy disease burden. Previous clinical practice guidelines of knee osteoarthritis mainly focused on tibiofemoral joint osteoarthritis, whereas PFOA has drawn more attention in recent years. Therefore, it is necessary to standardize the diagnosis and treatment of PFOA in the clinical setting. The Guideline Working Panel, consisted of clinical specialists in the field of orthopaedic joint surgery, adopted methods in accordance to WHO guideline handbook when making the present guideline. Firstly, several rounds of online survey of clinicians was conducted to determine important clinical questions. After reviewing of the literatures concerning published systematic reviews, clinical trials, and observational studies in the field of PFOA and evaluation of quality of the evidence found, determination of consensus recommendations and strength of these recommendations were performed following several rounds of Delphi process. Ultimately, a total of 12 recommendations, involving the diagnosis (symptoms, signs and imaging changes), non-surgical (primary treatment and pharmacotherapy) and surgical interventions (repair and reconstruction) of PFOA, were developed. The present guideline aimed to guide decision-making of diagnosis and treatment of PFOA in clinical practices in China.