Association between carotid atherosclerotic plaque and multiple Risk Factors
YUAN Ying, CHANG Fu-ye, HUANG Man-wei, SONG Xin, SUN Ying, LAI Jie, LI Yun-chao, LI Chang-xin, YUAN Xiang-zhi, HU Qiu-ying
Published 2011-10-01
Cite as , 2011,27(10): 1030-1034. DOI: 10.3760/cma.j.issn.1008-6315.2011.10.008
Abstract
Objective To investigate the relationship between carotid atherosclerotic plaque and multiple risk factors of angiocardiopathy,and to evaluate the injuries caused by different risk factors to subclinical target organ to control the general risk factors of angiocardiopathy.Methods Four hundred and twenty six outpatients and impatients,treated in our hospital from May 2007 to May 2009 with the results of color ultrasonic examination,were divided into carotid atherosclerotic plaque group(284 cases) and no carotid atherosclerotic plaque group( 142 cases).The clinical information including their age,body mass index,smoking condition,past medical history such as hypertension,diabetes mellitus and hyperlipoidemia were recorded,and the levels of total cholesterol(T C),high density lipoprotein cholesterol( HDL-C),low density lipoprotein cholesterol(LDL-C),triglyceride (TG),lipoprotein ( a ) ( LP (a) ),apolipoprotein A - 1 ( Apo A 1 ),apolipoprotein B ( Apo B ),highsensitivity C-reactive protein( hs-CRP),homocysteine ( HCY),microalbuminuria( MAU ) and uricacid(UA) were determined by lab tests.The independent variable and univariable data were processed and analyzed statistically to find out the risk factors of carotid atherosclerotic plaque.Results Age and drinking were significantly correlated with the carotid intima-media wall thickening(IMT) (P < 0.001 ).Overweight,diabetes mellitus,increased LP (a),hyperlipoidemia,age,increased MAU and HCY could independently predict carotid atherosclerosis and plaque formation ( x2 =71.35,38.45,t =3.26,x2 =37.23,t =118.51,6.723 and 3.17respectively,Ps < 0.05 ).The aggregated number of the risk factors was correlated to IMT and carotid atherosclerotic plaque ( P =0.0001 ).Conclusion Age,drinking,overweight,diabetes mellitus,increased LP (a),hyperlipoidemia,MAU and HCY are risk factors of carotid atherosclerosis and plaque formation,and the contribution of each factor can multiply and overlap,more risk factors means greater risk.
Key words:
Carotid atherosclerosis; Carotid atherosclerosis plaque; Multiple risk factors; General risk factors; Angiocardiopathy
Contributor Information
YUAN Ying
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China
CHANG Fu-ye
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China
HUANG Man-wei
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China
SONG Xin
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China
SUN Ying
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China
LAI Jie
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China
LI Yun-chao
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China
LI Chang-xin
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China
YUAN Xiang-zhi
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China
HU Qiu-ying
Department of Geratlogy, China Coal General Hospital,Beijing 100028, China