Objective To explore the risk factors of survival status of glioma patients with grade Ⅱ Screen.Methods Forty-two cases with brain glioma of Ⅱ cases diagnosed by pathology in the Fifth Affiliated Hospital of Zhengzhou University from Mar.2010 to Feb.2013 were enrolled in our study.All cases were performed glioma craniotomy operation.Survival quality score of KPS were calculated and classified according to the sex,age,preoperative neurological dysfunction,epilepsy history,tumor size,tumor depth.Studied the factors that influence the life quality of the patients.Results The indices of gender,preoperative neurological dysfunction and epilepsy history had not impacted on quality of life (P ＞ 0.05).However,the factors of age,tumor size,the depth and extent of resection affected the quality of life.KPS of patients more than 60 years was (12.8 ± 4.8),lower than that less than 60 years old (20.6 ± 8.7).KPS of patients with tumor diameter greater than or equal to 4 cm were (15.4 ± 5.2),less than that tumor diameter smaller than 4 cm (20.8 ± 6.3).KPS of patients with deep tumor,subtotal incision were (13.8 ± 6.2) and (14.3 ±5.8),lower than those of patients with superficial tumors and total resection ((21.2 ± 4.8),(19.8 ± 6.3)).The differences were significant(t =3.281,2.874,4.202,2.452 ; P ＜ 0.01 or P ＜ 0.05).All patients were followed up for (2.8± 1.1) years.The mortality rate was 7.1％ (2/42),and the relapse rate was 28.6％ (12/42).Conclusion The development and survival of patients with supratentorial Ⅱ glioma are related to age,tumor size,extent of resection range.Patients with older age,larger tumor size,deeper and subtotal resection have the worse quality of life.It should be done including paying more attention for this kinds of cases,monitoring frequency and improving the effect of comprehensive operation.