Cardiovascular Diseases
Relationship between the neutrophil to lymphocyte ratio and prehypertension
Jiang Wenyan, Gao Shujuan, Fu Wenjuan, Lu Xiangrong
Published 2018-09-01
Cite as Clin Med Chin, 2018,34(5): 399-402. DOI: 10.3760/cma.j.issn.1008-6315.2018.05.003
Abstract
ObjectiveTo investigate the relationship between the ratio of neutrophils to lymphocyte and prehypertension and its clinical significance.
MethodsIn May 2015, three thousand one hundred and twenty-six subjects who underwent physical examination in Tangshan People's Hospital Health Examination Center were enrolled in the study.120 cases of pre hyperton were selected as the observation group, and 120 with normal blood pressure were used as the control group.The neutrophils and lymphocyte counts of the subjects were detected.The relationship among the two groups of test indicators, the ratio of neutrophils to lymphocyte counts and blood pressure was analyzed.
ResultsThe ratio of neutrophil and lymphocytes in the observation group was(2.28±0.39), significantly higher than that in the control group(1.41±0.32)(t=1.196 P=0.028). According to the different ratio of neutrophils / lymphocytes, the patients were divided into 3 groups, group A (1.12±0.23), group B (1.73±0.08), group C (2.57±0.39), aling with the ratio increasing, the blood pressure increased, the systolic blood pressure of group A, B, C was (115±9) mmHg, (117±11) mmHg, (128±6) mmHg, respectively.The difference was statistically significant (F=4.404, P=0.013), the diastolic blood pressure of group A, B, C was (73±5) mmHg, (78±7) mmHg, (86±4) mmHg, respectively.The difference was statistically significant (F=4.553, P=0.027). Multivariate Logistic regression analysis showed that the ratio of neutrophils to lymphocytes was affected by systolic blood pressure, blood glucose, high density lipoprotein, BMI and triglyceride.
ConclusionThere is correlation between the ratio of neutrophil to lymphocyte and prehypertension, suggesting that inflammation may be involved in the occurrence and development of hypertension.
Key words:
Neutrophil to lymphocyte ratio; P rehypertension; Inflammatory
Contributor Information
Jiang Wenyan
Department of Cardiology, Tangshan People’s Hospital, Tangshan 063000, China
Gao Shujuan
Fu Wenjuan
Lu Xiangrong