Original Article
Correlation study between platelet function and immune parameters in septic patients
Liang Jifang, Wu Weidong, Yang Xiaojing, Wang Xiuzhe, Wu Wenjing, Shi Haipeng
Published 2019-01-01
Cite as Clin Med Chin, 2019,35(1): 45-48. DOI: 10.3760/cma.j.issn.1008-6315.2019.01.011
Abstract
ObjectiveTo explore the correlation between platelet function and immunity index in patients with sepsis.
MethodsThe platelet function and immune indexes of one hundred and one patients with sepsis treated in Shanxi Dayi Hospital from July 1st, 2016 to October 31st, 2017 were analyzed retrospectively.According to their shock, they were divided into shock group (34 cases) and non shock group (67 cases). Another 50 healthy people in the same period in our hospital were selected as control group.The relationship between platelet function and immune indexes was compared.
Results(1)the incidence of maximum blood block intensity decreased in the thrombus map of the septic shock group was higher than that in the non shock group, and the difference was statistically significant (65.67%(44/67) vs.23.53%(8/34), χ2=41.28, P<0.05); (2) the CD4+ T lymphocyte and C3 in the septic shock group were all lower than those in the non shock group ((47.28%±7.78) vs.(54.93%±11.26), t=3.554, P<0.05; (0.42±0.23) g/L vs.(0.75±0.19) g/L, t=-3.057, P<0.05), the ratio of CD4+ /CD8+ T lymphocyte was higher than that in non shock group ((2.68±0.18) vs.(2.45±0.07), t=7.18, P<0.001)). (3) the maximum intensity of blood clots was correlated with the percentage of CD4+ T lymphocyte, CD4+ /CD8+ T lymphocyte ratio, complement C3, acute physiology and chronic health status score system II score, and sequential organ failure score (r=0.617, 0.411, 0.563, -0.631, -0.547, P<0.01, or P<0.05).
ConclusionThrombocytopenia is present in septic patients, which is correlated with changes in immune indices.
Key words:
Sepsis; sepsis shock; thrombelastogram; immune index
Contributor Information
Liang Jifang
Department of Intensive Care Unit, Shanxi Dayi Hospital, Taiyuan 030032, China
Wu Weidong
Yang Xiaojing
Wang Xiuzhe
Wu Wenjing
Shi Haipeng