Original Article
Analysis of Radiotherapy optimization scheme after modified radical mastectomy
Zhe Hu, Haijiang Qu, Peien Wang, Beibei Miao, Yong Liang
Published 2019-03-01
Cite as Clin Med Chin, 2019, 35(2): 177-180. DOI: 10.3760/cma.j.issn.1008-6315.2019.02.019
Abstract
ObjectiveTo study the application value of radiotherapy optimization after modified radical mastectomy.
MethodsFrom January 2012 to January 2015, one hundred and twelve patients treated with modified radical mastectomy in Taizhou Cancer Hospital were enrolled and divided randomly into group A, B and C. 40 patients in group A received modulated radiation therapy(MRT) with 2.0Gy/f, 25 times, DT50Gy for 33-35d; 35 cases in group B received concurrent chemoradiotherapy with MRT and 37 cases in group C received concurrent chemoradiotherapy with large segmentation scheme of 2.66Gy/f, 16 times, DT42.56Gy for 22-24d.The recurrence rate, survival rate and the incidence of acute and chronic radiation injury of the 3 groups were compared.The parameters of V5, V10, V20 and V30 of ipsilateral lung was recorded by dose volume histogram(DVH).
ResultsThe total recurrence rate in group C was significantly lower than that of the other two groups (16.2%(6/37) vs.28.6%(10/35) vs.42.5%(17/40), χ2=6.409, P=0.041), while the total survival rate was significantly higher than that of the other two groups (89.2%(33/37) vs.77.1%(27/35) vs.65.0%(26/40), χ2=6.313, P=0.043), and there was no significant difference in the local recurrence and distant metastasis rate in the 3 groups (P>0.05). The incidence of total radiation injury in group C was lower than that of the other two groups (21.6% (8/37) vs.42.9% (15/35) vs.50% (20/40), χ2=6.973, P=0.031), and there was no significant difference in the incidence of acute and chronic injury and the grade of injury in the 3 groups (P>0.05). The values of V5, V10, V20 and V30 increased gradually in the 3 groups.The V5 and V10 in group C were significantly higher than those of the other two groups ((32.9±7.4)% vs.(17.5±5.9)% vs.(16.8±6.4)%, F=18.625, P=0.000, (42.4±7.3)% vs.(39.3±5.8)% vs.(35.5±6.0)%, F=15.624, P=0.000), and there was no significant difference in V20 and V30 among the three groups(P>0.05).
ConclusionThe combination of concurrent chemoradiotherapy and breast cancer after modified radical mastectomy is of great value in improving prognosis and reducing radiation damage.
Key words:
Modified radical mastectomy; radiotherapy; acute and chronic radiation injury; dose volume histogram
Contributor Information
Zhe Hu
Wenzhou Medical University, Wenzhou 325035, China (Hu Zhe is working on the Department of Breast，Taizhou Tumor Hospital，Taizhou，317500，China)
Haijiang Qu
Department of oncology, Taizhou Tumor Hospital, Taizhou 317500, China
Peien Wang
Department of oncology, Taizhou Tumor Hospital, Taizhou 317500, China
Beibei Miao
Department of oncology, Taizhou Tumor Hospital, Taizhou 317500, China
Yong Liang
Wenzhou Medical University, Wenzhou 325035, China
