Original Article
Diagnostic Value of Astograph Airway Responsiveness Measurement in Chest Suffocation Variant Asthma
Yunqiu Liu, Hemei Geng, Liying Zheng, Tianyu Cao, Weicun Liu, Zhenyan Chen, Liye Wang, Chunxia Xiu, Lu Song, Baoli Chen, xuan Lan
Published 2019-07-01
Cite as Clin Med Chin, 2019, 35(4): 342-346. DOI: 10.3760/cma.j.issn.1008-6315.2019.04.011
Abstract
ObjectiveTo investigate the diagnostic value of Astograph methacholine provocation test in patients with chest tightness variant asthma(CTVA).
MethodsFrom January 2011 to February 2017, 156 patients with CTVA in outpatient or inpatient department of respiratory medicine of Kailuan General Hospital affiliated to North China University of Science and Technology were selected as case group (chest tightness variant asthma group). The control group were 361 non-asthmatic patients including interstitial lung disease(23 cases), coronary disease (157 cases), hypertensive cardiopathy(22 cases), myocardiosis (16 cases), congenital heart disease (3 cases), rheumatic valvular heart disease (6 cases), central airway disease (3 cases), thyromegaly (10 cases), mediastinal tumor (5 cases), thoracic or spinal deformity (8 cases), phrenoparalysis (2 cases) and vegetative nerve functional disturbance (106 cases). All participants received pulmonay ventilation test, average daily and nightly variation rate of PEF(Peak expiratory flow) or PEF weekly variability, Astograph methacholine provocation test (forced expirataory volume in one second≥70% expectation), and other relevant examinations.The diagnostic value of Astograph methacholine provocation test on CTVA was assessed by analyzing the sensitivity, specificity, positive predictive value, negative predictive value, and Yunden index of Astograph methacholine airway.
ResultsCompared with the control group((1.18±0.44)%), theforced expiratory flow from 75% of Forced vital capcacity (FEF75)index of CTVA group((1.29±0.50)%) had significant difference(, t=2.96, P=0.006). The sensitivity, specificity, positive predictive value, negative predictive value, Yunden index, and diagnostic accuracy of Astograph methacholine provocation test on CTVA were 0.814, 0.695, 0.536, 0.305, 0.509 and 0.731, respectively.
ConclusionThe sensitivity, negative predictive value, Yunden index and diagnostic accuracy of Astograph methacholine provocation test on CTVA were higher, whereas the specificity and positive predictive value were relatively lower, suggesting that Astograph methacholine provocation test had a reliable diagnostic value on CTVA, with lower false negative and higher false positive.
Key words:
Astograph method; Chest tightness variant asthma; Diagnosis
Contributor Information
Yunqiu Liu
Department of Respiratory, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China
Hemei Geng
Department of Infection Management, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China
Liying Zheng
Department of Respiratory, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China
Tianyu Cao
Department of Health, 72nd Division of Hebei Army Reserve Artillery, Tangshan 063000, China
Weicun Liu
Department of Respiratory, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China
Zhenyan Chen
Medical Department of Kailuan Mental Health Center Affiliated to North China University of Science and Technology, Tangshan 063000, China
Liye Wang
Department of Respiratory, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China
Chunxia Xiu
Department of Respiratory, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China
Lu Song
Department of Respiratory, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China
Baoli Chen
Department of Obstetrics and Gynecology, Tangshan Maternal and Child Health Hospital of Hebei Province, Tangshan 063000, China
xuan Lan
Department of Respiratory, Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan 063000, China
