Clinical Investigations
Diagnostic value of CT guided percutaneous biopsy for peripheral solitary pulmonary ground-glass nodules
Du Haihao, Tan Xiongmu, Cheng Liuhui, Wang Yazhou, Dou Yunlong, Wang Daoqing
Published 2019-01-25
Cite as Int J Radiat Med Nucl Med, 2019,43(1): 27-31. DOI: 10.3760/cma.j.issn.1673-4114.2019.01.006
Abstract
ObjectiveTo evaluate the value of CT-guided percutaneous biopsy for diagnosis of solitary ground glass nodules(GGO) around the lung.
MethodsFifty-nine patients with solitary frosted glass nodules around the lungs who underwent CT examinations from January 2017 to December 2017 were enrolled in the study. All patients underwent CT-guided percutaneous biopsy, which was confirmed by surgery, clinical, or follow-up, in accordance with the maximum diameter of the lung GGO axial position, the proportion of solid components, the location of the lesion, the distance from the pleura, the angle of the needle-pleural, and the number of needle adjustments. Univariate analysis was used to determine the diagnostic accuracy, sensitivity, specificity, and incidence of complications. A chi-square test was used to compare the benign and malignant between solid components ≤50% and >50% in mixed GGO.
ResultsThe accuracy, sensitivity, and specificity of the diagnosis of 59 patients with solitary pulmonary GGO were 89.8%(53/59), 84.2%(32/38), and 100%(21/21), respectively, thereby confirming the disease as adenocarcinoma. According to different groups used in the method, the accuracy of the diagnosis is higher than 80%, the sensitivity is higher than 75%, and the specificity is 100%, but the incidence of overall complications is also higher. The difference between the mixed GGO solid components ≤50% and >50% was statistically significant(χ2=6.13, P<0.05).
ConclusionsCT-guided percutaneous biopsy has high diagnostic value for isolated GGO. The proportion of solid components in GGO has a certain correlation with the degree of malignancy.
Key words:
Tomography, X-ray computed; Solitary pulmonary nodule; Ground-glass nodule; Percutaneous biopsy
Contributor Information
Du Haihao
Department of Radiology, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
Tan Xiongmu
Cheng Liuhui
Wang Yazhou
Dou Yunlong
Wang Daoqing