Micro ribonucleic acid (miRNA) are highly conversed small noncoding RNAs that regulate gene expression on the post-transcriptional level,which are implicated in and play crucial roles in a variety of physiological processes,including glucose homeostasis.Angiogenesis and remodelling is necessary for the physiological function,plays critical roles in the tissue growth,development and the recovery of organ function,such as wound healing,regular change of endometrium in female menstrual cycle and collateral circulation establishment after vascular occlusion.There were abnormal expression of many kinds of miRNAs in diabetic patients such as the decreasing expression of miR-210,miR-93,and miR-126 which stimulate the angiogenesis,and the increasing expression of miR-320 and miR-503 which inhibit the angiogenesis.These abnormal miRNA involved in various diabetic chronic vascular diseases.Therefore,they may provide the potential molecular therapeutic targets for diabetic vascular complications such as cardiovascular and cerebral vascular disease,retinopathy and diabetic foot.