Resveratrol is a polyphenol compound originally extracted from giant knotweed,grape,and red wine.Previous research demonstrated calorie restriction has anti-aging effect.Recent studies showed that resveratrol could mimick calorie restriction,thereby play an positive role in anti-aging field.Moreover,it has anti-diabetic,cardioprotective and neuroprotective effects as well.The potential targets and the underlying mechanisms of resveratrol have begun to be elucidated.Meanwhile,accumulating data of its effectiveness and safety from clinical studies also contribute to pave the way for its further clinical application.