Complication of Anesthesia
Effects of ABO blood group factors on postoperative cognitive function in elderly patients
Wang Lihong, Yu Jianshe
Published 2015-11-20
Cite as Chin J Anesthesiol, 2015,35(11): 1331-1334. DOI: 10.3760/cma.j.issn.0254-1416.2015.11.012
Abstract
ObjectiveTo investigate the effects of ABO blood group factors on postoperative cognitive function in elderly patients.
MethodsOne hundred twenty patients, aged 65–75 yr, with body mass index of 17–26 kg/m2, of American Society of Anesthesiologists physical status Ⅰor Ⅱ, scheduled for elective thoracic surgery, were divided into 4 groups(n=30 each)according to the blood group: blood group A group(group A), blood group B group(group B), blood group O group(group O)and blood group AB group(group AB). Combined general-epidural anesthesia was used during surgery, patient-controlled epidural analgesia was performed after surgery, and visual analogue scale score was maintained ≤4.Before surgery(T0), and at 6, 24 and 72 h after surgery(T1-3), Mini-Mental State Examination(MMSE)was used to assess the cognitive function, and the occurrence of postoperative cognitive dysfunction(POCD)was recorded.Blood samples were drawn from the central vein at T0-3 for determination of neuron-specific enolase(NSE)and S-100β protein concentrations in serum.
ResultsCompared with the values at T0, MMSE scores were significantly decreased, and serum NSE and S-100β concentrations were increased at T1-3 in A, B and AB groups, and at T1 and T2 in group O(P<0.05). Compared with group A, MMSE scores were significantly increased, and serum NSE and S-100β concentrations were decreased at T1-3 in B, AB and O groups(P<0.05). Compared with group O, MMSE scores were significantly decreased, and serum NSE and S-100β concentrations were increased at T1-3 in B and AB groups(P<0.05). There was no significant difference in MMSE scores and serum NSE and S-100β concentrations at T1-3 between group B and group AB(P>0.05). The incidence of POCD from the high to the low was group A, group AB, group B, and group O in turn(P<0.05 or 0.01).
ConclusionABO blood group factors affect postoperative cognitive function in elderly patients, elderly patients of blood group A are found to be prone to develop POCD, and the incidence of POCD is relatively low for elderly patients of blood group O.
Key words:
ABO blood-group system; Aged; Postoperative complications; Cognition disorders
Contributor Information
Wang Lihong
Department of Anesthesiology, First Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010050, China
Yu Jianshe