General Anesthesia
Effects of hearing disorder factors on analgesic efficacy of propofol
Hongwei Wang, Dan Shen, Lanlan Li, Long He, Chenhui He, Wei Zhang, Yanqiu Ai, Qinjun Chu
Published 2018-01-20
Cite as Chin J Anesthesiol, 2018, 38(1): 52-54. DOI: 10.3760/cma.j.issn.0254-1416.2018.01.008
Abstract
ObjectiveTo evaluate the effects of hearing disorder factors on analgesic efficacy of propofol.
MethodsNinety-five patients with hearing disorders, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, aged 18-60 yr, with body mass index of 20-30 kg/m2, scheduled for elective ear surgery, served as test group(group T). Ninety-five patients with normal hearing function, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, aged 18-60 yr, with body mass index of 20-30 kg/m2, scheduled for elective non-ear surgery, served as control group(group C). Propofol was given at the initial target plasma concentration of 1.2 μg/ml.When the target plasma concentration was achieved, 1 min later the concentration was increased in increments of 0.3 μg/ml.When the patients lost eyelash reflex and had no responses to clapping on the shoulder, bispectral index value and target plasma and effect-site concentrations of propofol, consumption of propofol and time for loss of consciousness were recorded.
ResultsCompared with group C, no significant change was found in bispectral index value at baseline or at loss of consciousness(P>0.05), the target plasma and effect-site concentrations and consumption of propofol were significantly decreased, and the time for loss of consciousness was shortened in group T(P<0.05). The consumption of propofol required at loss of consciousness was gradually reduced with the aggravated severity of hearing disorders in group T(P<0.05).
ConclusionThe analgesic efficacy of propofol is enhanced in the patients with hearing disorders.
Key words:
Hearing disorders; Propofol; Conscious sedation
Contributor Information
Hongwei Wang
Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Dan Shen
Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Lanlan Li
Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Long He
Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Chenhui He
Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Wei Zhang
Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Yanqiu Ai
Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Qinjun Chu
Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
