General Anesthesia
Effect of dexmedetomidine on postoperative cellular immune function in patients with malignant tumor: a meta-analysis
Chen Jie, Ji Fang, Lei Zhong, Zhang Jingjing, Yiheshan Ainiwaer, Zhang Bing
Published 2018-04-20
Cite as Chin J Anesthesiol, 2018,38(4): 454-457. DOI: 10.3760/cma.j.issn.0254-1416.2018.04.019
Abstract
ObjectiveTo systematically evaluate the effect of dexmedetomidine on postoperative cellular immune function in patients with malignant tumor.
MethodsThe Medline, Cochrane Library, EMBASE, PubMed, OVID, Superstar Foreign Languages Database and Chinese Database, CNKI, Chinese Biomedical Literature CD-ROM Database and Wanfang Database were searched, and the publication was not limited by language or time.The randomized controlled trials involving the effect of dexmedetomidine on postoperative cellular immune function in patients with malignant tumor were collected.The evaluation indexes included the levels of whole blood T lymphocyte subsets CD3+ , CD4+ , CD8+ and natural killer cells and ratio of CD4+ /CD8+ .Meta-analysis was conducted using the Cochrane Collaboration′s RevMan 5.2 software.
ResultsTwelve prospective randomized controlled trials involving 692 patients were included in our meta-analysis.Compared with control group, the levels of CD3+ , CD4+ and natural killer cells and ratio of CD4+ /CD8+ were significantly increased at 1 day after operation (P<0.01), and no significant change was found in the level of CD8+ in dexmedetomidine group (P>0.05).
ConclusionDexmedetomidine can improve postoperative cellular immune function in patients with malignant tumors.
Key words:
Dexmedetomidine; Tumor; Cellular immunity; meta analysis
Contributor Information
Chen Jie
Department of Anesthhesiology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China
Ji Fang
Department of Anesthhesiology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China
Lei Zhong
Department of Anesthhesiology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China
Zhang Jingjing
Department of Anesthhesiology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China
Yiheshan Ainiwaer
Department of Anesthhesiology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China
Zhang Bing
Department of Anesthhesiology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China
