Critical Care Medicine
Accuracy of serum pro-adrenomedullin concentration in predicting sepsis at different degrees of severity
Lai Wang, Mengsha Zhu, Fang Wang, Xiufen Yang
Published 2018-05-20
Cite as Chin J Anesthesiol, 2018, 38(5): 595-597. DOI: 10.3760/cma.j.issn.0254-1416.2018.05.023
Abstract
ObjectiveTo evaluate the accuracy of serum pro-adrenomedullin(pro-ADM) concentration in predicting sepsis at different degrees of severity.
MethodsA total of 145 patients of both sexes, aged 18-64 yr, who were admitted to intensive care unit (ICU) of the First Hospital of Hebei Medical University from March 2015 to April 2017, with length of ICU stay>24 h, were enrolled.The patients were divided into 3 groups according to the Sequential Organ Failure Assessment (SOFA) score within 24 h after admission to ICU: 2<SOFA score≤6 mild sepsis group (n=50), 6<SOFA score≤12 moderate sepsis group (n=50) and SOFA score>12 severe sepsis group (n=45). Peripheral venous blood samples were collected immediately after admission to hospital for determination of serum pro-ADM concentrations by enzyme-linked immunosorbent assay.The receiver operating characteristic (ROC) curve of pro-ADM in predicting sepsis at different degrees of severity was plotted, and the area under the curve and 95% confidence interval, cut-off value, sensitivity and specificity were calculated.
ResultsThe serum pro-ADM concentrations were significantly increased with the severity of sepsis, and the length of ICU stay was prolonged with the severity of sepsis (P<0.05). In mild sepsis group, the area under the ROC curve was 0.770, 95% confidence interval 0.591-0.949, sensitivity 0.725, specificity 0.700 and cut-off value 6.45 nmol/L.In moderate sepsis group, the area under the ROC curve was 0.776, 95% confidence interval 0.645-0.907, sensitivity 0.813, specificity 0.760, cut-off value 8.30 nmol/L.In severe sepsis group, the area under the ROC curve was 0.83, 95% confidence interval 0.715-0.963, sensitivity 0.73, specificity 0.800, cut-off value 5.70 nmol/L.
ConclusionSerum pro-ADM concentration can be used as a reliable index in predicting sepsis at different degrees of severity.
Key words:
Adrenomedullin; Sepsis
Contributor Information
Lai Wang
Department of Critical Care Medicine, First Hospital of Hebei Medical University, Shijiazhuang 050031, China
Mengsha Zhu
Department of Critical Care Medicine, Hebei Children′s Hospital, Shijiazhuang 050031, China
Fang Wang
Department of Critical Care Medicine, First Hospital of Hebei Medical University, Shijiazhuang 050031, China
Xiufen Yang
Department of Critical Care Medicine, First Hospital of Hebei Medical University, Shijiazhuang 050031, China
