Complication of Anesthesia
Outcome of long-term cognitive function after liver transplantation in children: role of age factor
Zhu Hui, Jiang Xuliang, Huang Lili, Zhang Xiao, Tian Weitian, Su Diansan, Yu Weifeng
Published 2019-10-20
Cite as Chin J Anesthesiol, 2019,39(10): 1165-1167. DOI: 10.3760/cma.j.issn.0254-1416.2019.10.005
Abstract
ObjectiveTo evaluate the outcome of long-term cognitive function after liver transplantation in children and the role of age factor.
MethodsNinety-five pediatric patients, aged 2 yr and 6 months to 6 yr and 11 months at test, at least 1 yr after liver transplantation, were selected.The children′s cognitive function was assessed using Chinese Wechsler Intelligence Scale for Children.The patients were divided into 2 groups according to the age at transplantation: ≤1 yr group (L1 group, n=65) and > 1 yr group (M1 group, n=22).
ResultsCompared with the normal value, the scores of verbal comprehension and total intelligence quotient (IQ) were significantly decreased, and the proportion of children who had above-average IQ was decreased 1 yr after liver transplantation, the scores of verbal comprehension were decreased, and the proportion of children who had above-average IQ was decreased in group L1, and the scores of verbal comprehension, visual space and total IQ were significantly decreased, the proportion of children who had above-average IQ was reduced, and the proportion of children who had below-average IQ was increased in group M1(P<0.05). Compared with L1 group, the total IQ score was significantly decreased, the proportion of children who had above-average IQ was reduced, and the proportion of children who had below-average IQ was increased in group M1 (P<0.05).
ConclusionThe long-term cognitive function of children after liver transplantation is lower than that of normal children, and the long-term cognitive function of children ≤1 yr is better than that of children >1 yr.
Key words:
Liver transplantation; Cognition; Child; Age factors
Contributor Information
Zhu Hui
School of Medicine, Soochow University, Suzhou 215123, China
Jiang Xuliang
Department of Anesthesiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Huang Lili
Department of Anesthesiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Zhang Xiao
Department of Anesthesiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Tian Weitian
Department of Anesthesiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Su Diansan
Department of Anesthesiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Yu Weifeng
Department of Anesthesiology, Estern Hepatobiliary Surgery Hospital, Shanghai 200438, China
