Objective To investigate the left ventricular(LV)rotation and twist in patients with ventricular septal defect(VSD)after transcatheter closure of VSD.Methods Using speckle tracking imaging(STI),the roation of 6 segments of basal and apical short-axises and LV twist were measured repeatedly in 36 patients with VSD before closure and in 3rd day after closure.The peak roation of 6 segments of basal and apical short-axises and peak global roation of the basal and apical short-axises and peak LV twist were caculated.LV end-diastolic diameter(LVEDd)and LV end-diastolic volume(LVEDV)were caculated.LV ejection fraction(LVEF)was measured by biplane Simpson method.Results The peak roation of basal and apical short-axises and peak twist of LV twist in 3rd day after closure were lower(P<0.05).LVEDd and LVEDV were significantly reduced in 3rd day after closure(P<0.05).There were no significant differences in LVEF.The peak twist of LV had a significant correlation with LVEF and LVEDV.Conclusions LV roation and twist may be a new index for predicting LV systolic function.