Clinical Research
The value of conventional ultrasound combining with contrast-enhanced ultrasound in the diagnosis of xanthogranulomatous cholecystitis
Yuan Haixia, Guan Peishan, Lin Lewu, Chen Xuejun, Huang Beijian, Wang Wenping
Published 2019-01-25
Cite as Chin J Ultrasonogr, 2019,28(1): 60-65. DOI: 10.3760/cma.j.issn.1004-4477.2019.01.013
Abstract
ObjectiveTo explore the value of contrast-enhanced ultrasound (CEUS) in improving the diagnosis ability for xanthogranulomatous cholecystitis (XGC) and wall-thickening gallbladder cancer (GBC).
MethodsForth-three patients with XGCs and 31 patients with wall-thickening GBCs proved by pathology were enrolled in this study, the features on conventional ultrasound and CEUS were recorded, and the preliminary diagnosis before and after CEUS were given by doctors.
ResultsSignificant differences were found in continuous gallbladder inner wall and arterial blood supplement on conventional ultrasound, 58.1% (25/43) had continuous inner wall and 34.9% (15/43) had arterial blood flow in XGCs compared to 19.4% (6/31) and 100% in GBCs. On CEUS, 72.1% (31/43) demonstrated continuous gallbladder inner wall and 48.8% (21/43) had hypoechoic nodules in the wall in XGCs compared to 16.1% (5/31) and 19.4% (6/31) in GBCs, respectively (P<0.05). No significant difference was found in intra-calcification, infiltration to adjacent organs, gallbladder stones and fast-in and fast-out enhanced pattern(P>0.05). The area under ROC curve was improved from 0.701 to 0.899 after combining with CEUS (P<0.05).
ConclusionsConventional ultrasound combining with CEUS could help acquiring more effective ultrasonic information and may improve the differential diagnosis ability of XGCs and GBCs.
Key words:
Contrast-enhanced ultrasound; Xanthogranulomatous cholecystitis; Wall-thickening gallbladder cancer; Diagnostic ability
Contributor Information
Yuan Haixia
Department of Ultrasound, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Guan Peishan
Department of Ultrasound, Xiamen Branch, Zhongshan Hospital of Fudan University, Xiamen 361015, China
Lin Lewu
Department of Ultrasound, Xiamen Branch, Zhongshan Hospital of Fudan University, Xiamen 361015, China
Chen Xuejun
Department of Ultrasound, Xiamen Branch, Zhongshan Hospital of Fudan University, Xiamen 361015, China
Huang Beijian
Department of Ultrasound, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Wang Wenping
Department of Ultrasound, Zhongshan Hospital of Fudan University, Shanghai 200032, China
