To explore the clinical application value of high-frequency contrast-enhanced ultrasound in guiding peripheral lung consolidation biopsy.

Clinical data of 33 patients with peripheral pulmonary who underwent high-frequency contrast-enhanced ultrasound biopsy were retrospectively analyzed. According to the pathological results as the gold standard, the puncture path, needle tip display, puncture complications and the diagnostic rate of pathological results were described.

Among the 33 patients, 32 patients had pathological findings, including 18 malignant lesions, 14 benign lesions, and 1 non-effective tissue. ①The difference between lesion enhancement and peripheral lung tissue enhancement time within 2.5 s were in 20 patients (12 benign, 8 malignant), 12 patients (2 benign, 10 malignant) showed difference greater than 2.5 s. There were 19 cases with uniform enhancement, including 9 benign cases (28.1%), 10 malignancy cases (31.3%); 13 cases with uneven enhancement, including 5 cases with benign (15.6%), 8 cases with malignancy (25.0%). The rate of relatively uneven enhancement of malignant lesions was higher, but the difference was not statistically significant(P=0.618). ②High-frequency contrast-enhanced images were scored at 2 points or more in 28 cases (87.5%), and the high-frequency contrast-enhanced ultrasound images were satisfactory. ③Interventional puncture path score was 2 points or more in 29 cases (90.6%). ④Puncture needle tip display were scored at 1 point or more in 28 cases (87.5%). ⑤A total of 87 needles were punctured, and 32 cases obtained pathological diagnosis of puncture (97.0%, 32/33).

Due to its high spatial resolution, high-frequency ultrasound can avoid adjacent tissues and blood vessels by showing the position of the needle tip in real time without the need of puncture frame and multi-angle needle insertion during operation, and accurately locate the target with good safety.

Contrast-enhanced ultrasound; High-frequency ultrasound; Lung; Puncture biopsy