Signal transducer and activator of transcription 6 (STAT6) are important in the pathogenesis of bronchial asthma(asthma), which regulate the activity of Th2 cell and the development of airway inflammation by eosinophilia. Peroxisome proliferator-activated receptor-γ(PPAR-γ) proves to inhibite the airway inflammation and remodeling by reducing the release of cytokine and inflammatory mediators,and by down-regulating the function of inflammatory cells. Recent studies suggested that PPAR-γ and glucocorticoid has a coordinated antiinflammatory effects, and moreover, both PPAR-γ and glucocorticoid could obviously inhibit STAT 6. In order to provide another way for asthma clinical therapy, the article reviews the functions of STAT 6 in the inflammation of asthma,and the effects of PPAR-γ and glucocorticoid on the treatment of asthma.