ObjectiveTo investigate the low-dose heparin in patients with sepsis of hypereoagulability. Methods Thirty normal adults were enrolled to measure the prothrombin fragment (F1 +2) and thrombin-antithrombin complex (TAT) level of blood plasma for the reference value. Twenty-seven eases of adult patients in sepsis hypercoagulable period were randomly divided into heparin-treatment group (the experiment) and non-heparin treatment group(the control). Twenty-seven patients were given routine anti-infective, early-goal fluid resuscitation treatment, while the experiment group given early use of continuous low-dose heparin (70 U/kg 24 h) pump except for the conventional treatment. The levels of FI+ 2 and TAT in the patients of both groups before and after 5 days" treatment were monitored, and the APACHE-I1 score,the days admitted to the ICU, the use time of respirator and the mortality of 28 days were calculated. Results F1 + 2 and TAT levels in the experiment group decreased significantly after the heparin treatment as compared with those before treatment( P = 0. 000,0. 042). But those in the control group were no significant( P =0. 742,0. 208). The days of using the ventilator and admitting in ICU in the experiment group were shorter than those of the control group (9. 25±6. 02) d, (10. 33±5.50) d vs (17.20±9.48) d, (16.20 ± 10. 03) d ( P = 0. 045, 0. 036). The APACHE-Ⅱ score in both groups reduced, butshowed significant difference in the experiment group( P = 0. 027). 28-day survival rates between the twogroups had no significant difference( P =0. 643). Conclusions The early low-dose heparin in the treatmentof the sepsis in hypercoagulability can improve the hypercoagulable situation, lessen the length of hospitalstay,but fails to improve the survival rate.