Oxygen uptake kinetics daring exercise in patients with severe chronic obstructive pulmonary disease
LIU Pan-pan, LIU Jin-ming, YANG Wen-lan
Published 2011-05-05
Cite as Int J Respir, 2011,31(09): 672-676. DOI: 10.3760/cma.j.issn.1673-436x.2011.009.009
Abstract
Objective The aim of the current study was to determine if the slowed exercise oxygen uptake (VO2) kinetics would be accompanied by delayed recovery VO2 kinetics in patients with severe chronic obstructive pulmonary disease (COPD). Methods We evaluated 37 patients with severe COPD and 17 normal people, who had the pulmonary function test(PFT)and cycle ergo meter cardiopulmonary exercise test (CPET) studies to maximum tolerance. Gas exchange was calculated breath by breath.Results MRT and τRec for VO2 in patients with COPD were consistently found longer than the controls ( P<0. 010),and correlated well with peak VO2, peak VO2 % pred, VO2/kg and VE( P <0.001), also the parameters from PFT, such as FEV1% pred. FEV1/FVC、 MVV% pred. RV% pred、 RV/TLC and Rtot%pred( P<0.001). Conclusions Exercise and recovery VO2 kinetics were slowed. Measurement of exercise and recovery VO2 kinetics improve the accuracy of the exercise electrocardiogram diagnosis of COPD.
Key words:
Cardiopulmonary exercise test; Oxygen uptake kinetics; Chronic obstructive pulmonary disease
Contributor Information
LIU Pan-pan
Department of Respiratory Medicine,Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai 200433 ,China
LIU Jin-ming
Department of Respiratory Medicine,Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai 200433 ,China
YANG Wen-lan
Department of Respiratory Medicine,Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai 200433 ,China