Chronic obstructive pulmonary disease (COPD)is a common lung disease.The development of venous thromboembolism(VTE) in patients with COPD,especially in its acute episode,has received more and more our attentions.Researehs of pathogenesis and diagnosis methods of VTE in patients with the acute exacerbations of COPD (AECOPD),as long as the research of prethrombotie state (PTS) is now the hot spot.Patients with COPD exist PTS has become a widely accepted fact.However it is no unified PTE related diagnostic criteria,so it is difficult to provide a basis for clinical treatment.By consulting some reference,the pathogenesis,diagnosis and anticoagulant therapy of VTE in patients with AECOPD were reviewed in this article,so as to providing informations for further work.