ADAM33 gene is a newly identified member of a disintegrin and metalloproteinase ADAM family,the single nucleotide polymorphisms of ADAM33 gene is involved in bronchial asthma (asthma),bronchial hyper-responsiveness and the severity of asthma.Moreover,it is associated with accelerated early-life lung function and the decline of forced expiratory volume in 1 second.Smoking can increase airway responsiveness and airway remodeling,resulting in a difficulty of controlling asthma.It has been confirmed that this may occur via interaction of smoking with ADAM33 gene.This articlereviewed the role of ADAM33 gene in asthma and the effects of smoking on ADAM33 gene.