Objective We aimed to investigate the level of anti-Hp-IgG,IL-6 and IL-17 in helicobacter pylori (Hp) patients with chronic obstructive pulmonary disease (COPD) to determine whether there is an association between Hp infection and COPD.Methods We evaluated 31 COPD patients [20 males and 11 females,aged (62.74 ± 4.27) years] and 30,age and sex-matched,control subjects.All subjects enrolled underwent an enzyme-linked immunosorbent assay (ELISA) test for antiHp-IgG,IL-6 and IL-17.We also test forced expiratory volume in 1 s (FEV1) values,which indicate the severity of COPD.Results Serum levels of Hp-specific IgG were significantly higher in the patients with COPD than in the control subjects (P =0.042).Inaddition,Hp serum IgG levels were correlated with FEV1 values(r =-0.662,P ＜0.001);Serum levels of IL-6 and IL-17 were significantly higher in the patients with COPD than in the control subjects (P ＜0.001,P =0.036,respectively).Moreover,serum IL-17 levels were correlated with FEV1 values(r =-0.615,P ＜0.001)and Hp serum IgG levels (r =0.671,P ＜0.001).Conclusions The results suggest that there is an association between Hp infection and COPD.Mybe the reason is associated to IL-17 actived.