Objective To discuss the curative effect of Combivent in treating bronchiectasis with inreversible airway obstruction.Methods Retrospective analysis of 86 acute exacerbation bronchiectasis inpatients with inreversible airway obstruction verified by lung function test when admitted to hospital,were divided into 2 groups:control group (n =39) received conventional therapy and Combivent group (n =47) received combivent 2.5 ml nebulized every 6 hours a day combined with conventional therapy.The course of treatment was 1 week.The clinical symptoms,pulmonary functions,curative effect judgement and adverse effect were compared between two groups after treatment.Results Clinical symptoms were improved in Combivent group (2.2± 1.0 after treatment compared with 6.4±1.6 before treatment) and control group (2.8 ± 1.5 after treatment compared with 6.0 ± 1.7 before treatment).There was significant difference than before treatment in each group (t =10.2 and t =15.5 respectively,P ＜0.01).There was also significant difference between two groups (2.2 ± 1.0 in Combivent group vs 2.8 ± 1.5 in control group) after treatment (t =2.33,P ＜0.05).FEV1 ％pred was (47.14±5.49) ％ after treatment compared with (45.26 ± 4.72)％ before treatment in Combivent group.The total effective rate is 93.6 ％,mean hospitalization day is 8,2 and adverse reaction incidence is 2.1 ％.While FEV1 ％ pred was (51.62 ± 4.23) ％ after treatment compared with (48.01±5.46)％ before treatment in Combivent group.The total effective rate is 89.7％,mean hospitalization day is 9.7 and adverse reaction incidence is 2.6％.Lung function,curative effect and adverse effect have no difference between two groups after treatment.Conclusions Combivent has the effect of relaxing airway,accelerating sputum excretion,relieving clinical symptoms in treating acute exacerbation of bronchiectasis with inreversible airway obstruction,through it has no effect on lung function improvement in such short term usage.