To investigate the clinical manifestations of invasive pulmonary aspergillosis (IPA) in patients with chronic obsturctive pulmonary diease (COPD), and raise the awareness of the disease and ensure early detection, early diagnosis and early treatment.

Clinical data of 5 COPD patients complicated with IPA from respiratory intensive care unit (RICU) in Xijing Hospital during June 2015 and March 2016 were retrospectively analyzed.

There were 5 patients diagnosed as COPD with IPA, and three cases fulfilled criteria of proven IPA, 2 of probable IPA.All patients were treated with multiple broad-spectrum antibiotics and 4 patients were also treated with corticosteroids.All patients showed severe bronchospasm and 4 of them needed noninvasive ventilation but all failed and 2 patients requierd invasive ventilation.Radiological finding were non-specific change in the early stage but multiple infiltrates or consolidation in the peribronchovascular at the progression stage.Bronchoscopy showed tracheobronchial inflammatory and bronchial pseudomembrane in the different period.The disease had a rapid progress and high mortality.

COPD patients combined with IPA may progress rapidly and lead a high mortality.Early diagnosis and treatment based on certain clinical features may reduce the risk of death.

Chronic obsturctive pulmonary diease; Invasive pulmonary aspergillosis; Clinical feature