Original Article
Study on the safety of bronchoalveolar lavage in patients with AECOPD and type Ⅱ respiratory failure during non-invasive positive pressure ventilation
Zheng Yan, Li Yumei, Tang Wenli, Zhu Lili
Published 2018-09-20
Cite as Int J Respir, 2018,38(18): 1377-1380. DOI: 10.3760/cma.j.issn.1673-436X.2018.18.004
Abstract
ObjectiveTo investigate the safety of bronchoalveolar lavage (BAL) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and type Ⅱ respiratory failure patients during mon-invasive positive pressure ventilation (NIPPV).
Methods80 patients with AECOPD combined with type Ⅱ respiratory failure admitted between January 2016 and April 2017 in the Fourth Affiliated Hospital of Harbin Medical University were randomly divided into treatment group and control group, 40 cases in each group.The two groups were given NIPPV on the basis of routine treatment.The treatment group was given BAL at the same time as NIPPV treatment.The blood gas indexes, heart rate, changes in mean arterial pressure, and incidence of adverse reactions were compared between the two groups before given BAL and after 30 min, 1 h, 2 h.
ResultsThere was no significant difference in heart rate and mean arterial pressure between the two groups at each time (all P>0.05). Arterial partial pressure of oxygen values in the observation group were significantly higher than those in the control group at each time (all P<0.05); Arterial partial pressure of carbon dioxide decreased significantly compared with the control group, and the difference between the two groups was statistically significant (all P<0.05). There were 24 cases of adverse reactions in the observation group, including nine cases of abdominal distension, 11 cases of oral and nasal dryness, and four cases of arrhythmia; there were 21 cases of adverse reactions in the control group, including 10 cases of abdominal distention, eight cases of oral and nasal dryness, and three cases of arrhythmia.There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).
ConclusionsThe safety of BAL lavage during the NIPPV of patients with AECOPD and type Ⅱ respiratory failure is good, and the improvement of ventilation function is more significant.
Key words:
Non-invasive positive pressure ventilation; Bronchoalveolar lavage; Acute exacerbation of chronic obstructive pulmonary disease; Type Ⅱ respiratory failure
Contributor Information
Zheng Yan
Department of Respiratory Medicine, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Li Yumei
Tang Wenli
Zhu Lili
