Original Article
Protect effect of vitamin C on the oxidative injury by PM2.5
Shuzhi Han, Haiyue Li, Huipeng Liang, Fengrui Zhang, Fen Ping
Published 2019-03-20
Cite as Int J Respir, 2019, 39(6): 413-416. DOI: 10.3760/cma.j.issn.1673-436X.2019.06.003
Abstract
ObjectiveTo explore the protective effects of vitamin C on the oxidative injury by fine particulate matter 2.5 (PM2.5).
MethodsThirty-two healthy adult male wistar rats were selected.We used random number table method and divided patients into four groups(n=8): control group, normal saline group, PM2.5 group, vitamin C group.Pathological morphologic changes were observed under light microscope.MDA、8-OHdG and Hcy in serum were examined.
ResultsInfiltration of inflammatory cells, destroyed alveolars, thickened alveoli septum was noted in PM2.5 group, and we found that the exudation of inflammatory cells in alveolar space and impairment of lung tissue reduced in the vitamin C groups.The levels of MDA、8-OHdG and Hcy in serum increased in PM2.5 group compared with the control group and normal saline group.The levels of MDA, 8-OHdG and Hcy in serum were decreased in vitamin C groups.
ConclusionsVitamin C plays an antioxidant role in rat oxidative injury models exposed to PM2.5.
Key words:
Ascorbic acid; Particulate matter; Oxidative injury
Contributor Information
Shuzhi Han
Third Division of Geriatrics, Hebei General Hospital, Shijiazhuang 050051, China
Haiyue Li
Department of Respiration Medicine, Affiliate Hospital of Chengde Medical University, Chengde 067000, China
Huipeng Liang
Department of Tuberculosis, Hebei Chest Hospital, Shijiazhuang 050048, China
Fengrui Zhang
Third Division of Geriatrics, Hebei General Hospital, Shijiazhuang 050051, China
Fen Ping
Third Division of Geriatrics, Hebei General Hospital, Shijiazhuang 050051, China
