Original Article
Recent clinical efficacy of bronchial thermoplasty in the treatment of severe bronchial asthma
Liu Fenghui, Xu Junfa, Huang Wenting, Zheng Biying, Zhang Junai, Long Fa
Published 2019-08-20
Cite as Int J Respir, 2019,39(16): 1244-1248. DOI: 10.3760/cma.j.issn.1673-436X.2019.16.010
Abstract
ObjectiveTo investigate the short-term clinical efficacy of bronchial thermal plasty in the treatment of severe bronchial asthma (asthma).
MethodsThirty patients with severe asthma were treated by bronchial thermoplasty.The peripheral blood inflammatory cells, asthma quality of life questionnaire (AQLQ) and asthma control questionnaire (ACQ) scores, and lung function indexes such as forced vital capacity (FVC), forced expiratory volume in one second (FEV1), the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) and peak expiratory flow (PEF) were analyzed before and after treatment.
ResultsCompared with prior treatment(PT), after the first treatment(AFT) showed no significant difference in leukocyte and the ratio of neutrophils, lymphocytes and eosinophils, AQLQ improved significantly (t=10.23, P<0.01), ACQ (t=12.31, P<0.01) scores improved significantly, after the second treatment (AST) showed a significant decrease in leukocytes (t=3.135, P<0.01) and a significant decrease in the ratio of neutrophils (t=3.041, P<0.01), the ratio of lymphocytes increased (t=2.20, P<0.01) and the ratio of eosinophils increased (t=2.172, P<0.05), AQLQ scores improved significantly (t=15.80, P<0.01) and ACQ (t=14.30, P<0.01) scores improved significantly, FEV1 increased significantly (t=7.96, P<0.01). The neutrophil ratio in AFT group was positively correlated with FEV1 and PEF (r=0.391 3, 0.373 4, both P<0.05).
ConclusionsBronchial thermoplasty can improve inflammation and quality of life in patients.
Key words:
Asthma, bronchial; Clinical efficacy; Bronchial thermoplasty
Contributor Information
Liu Fenghui
Institute of Laboratory Medicine, Guangdong Medical University, Dongguan, 523808, China
Xu Junfa
Institute of Laboratory Medicine, Guangdong Medical University, Dongguan, 523808, China
Huang Wenting
Department of Respiratory Medicine, Shenzhen Hospital of Chinese Academy of Sciences, Shenzhen 518106, China
Zheng Biying
Institute of Laboratory Medicine, Guangdong Medical University, Dongguan, 523808, China
Zhang Junai
Institute of Laboratory Medicine, Guangdong Medical University, Dongguan, 523808, China
Long Fa
Department of Respiratory Medicine, Shenzhen Hospital of Chinese Academy of Sciences, Shenzhen 518106, China