To explore the incidence of low-T3 syndrome in patients with hematogenous disseminated pulmonary tuberculosis and tubercular meningitis and predictive value of T3 level for the prognosis.

Patients with hematogenous disseminated pulmonary tuberculosis and tubercular meningitis were retrospectively included into this study.Patients were divided into the dead group and the surviving group according to the incidence of all-cause death within 30 d. Univariate analysis was used to find differences between the two groups in baseline values.Then multiple logistic regression analysis was adopted to discover the predictive value for the poor prognosis in patients with hematogenous disseminated pulmonary tuberculosis and tubercular meningitis.

A total of 573 patients were included into this study, in which 259 patients suffered from low-T3 syndrome (with an incidence of 45.2%). Univariate analysis showed that the dead group had a higher age and acute physiology and chronic health evaluation (APACHE Ⅱ) score, a lower T3 level, a higher incidence of hyperlipoidemia and low-T3 syndrome compared with the surviving group.Multiple logistic regression analysis showed that T3 level (OR=0.256, 95% CI: 0.141-0.467), age (OR=1.106, 95% CI: 1.028-1.201) and left ventricular ejection fraction (OR=1.458, 95% CI: 1.096-1.985) were the independent risk factors for the poor prognosis in patients hematogenous disseminated pulmonary tuberculosis and tubercular meningitis.

The incidence of low-T3 syndrome in patients with hematogenous disseminated pulmonary tuberculosis and tubercular meningitis is high and serum T3 level is an important predictive factor for short-term poor prognosis.

Tuberculosis, pulmongary; Euthyroid sick syndromes; Prognosis