Clinical Research
Clinical efficacy and immunoregulation effects of iguratimod on Th subsets in patients with rheumatoid arthritis
Zhu Qi, Song Jinglue, Xu Yunzhi, Liu Hongli, Miao Yutong, Yang Fan, Wang Feiyan, Chen Guangjie, He Dongyi, Niu Xiaoyin
Published 2016-02-15
Cite as Chin J Rheumatol, 2016,20(2): 93-99. DOI: 10.3760/cma.j.issn.1007-7480.2016.02.005
Abstract
ObjectiveRheumatoid arthritis (RA) is a systemic autoimmune disease, which mainly involves joints across the body, resulting in joint stiffness and loss of daily activity. Recent evidence suggests that numerous self-reacting T cells, including Th1 and Th17, infiltrate the synovium in RA patients, accompanied by functionally-compromised Treg. Iguratimod, a new small molecule with anti-inflammatory and immunomodulatory effects, has shown curative effects in animal models of arthritis. In this study, we aimed to test the clinical effects of Iguratimod's on RA patients and its role in immunoregulation.
MethodsWe examined the clinical effects of iguratimod on RA patients in a random controlled clinical trials and analyzed its effects on Thl, Th17 and Treg as well as their associated cytokines and transcription factors by flow cytometry and real-time polymerase chain reaction (PCR). Then t-test, chi-square test and rank sum test were used to conduct statistical analysis.
ResultsOur results revealed that iguratimod therapy provided significantly greater clinical benefit [ACR20, ACR50, ACR70 reached 50%, 20%, 15% respectively in iguratimod treatment group, Z=-2.216,P=0.027] than placebo group with the reduction of Th1 and Th17 but increment of Treg after iguratimod treatment [Th1: week 0 (26.5±8.0)%, week 24 (14.2±7.3)%, P<0.01; Th17: week 0 (1.7±0.7)%, week 24 (1.3±0.4)%, P<0.05; Treg: week 0 (6.8±1.6)%, week 24 (8.9±2.9)%, P<0.05], which was statistically significant.
ConclusionOur results provide theoretical and clinical based evidence for the impact of iguratimod on immunomodulation of RA.
Key words:
Arthritis, rheumatoid; Iguratimod; Treatment outcome; Immunoregulation; T-lympho-cytes, helper-inducer
Contributor Information
Zhu Qi
Department of Rheumatology Guanghua Integrative Medicine Hospital, Shanghai 200052, China
Song Jinglue
Shanghai Jiaotong University School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, China
Xu Yunzhi
Liu Hongli
Miao Yutong
Yang Fan
Wang Feiyan
Chen Guangjie
He Dongyi
Niu Xiaoyin