Objective To compare the treatment effect of two different strategies of containment neo-vascularization by solving retinal hypoxia with reducing aqueous humor flow or finding another filtration channel due to obstruction of anterior chamber angle neovascularization, and to evaluate which methods had more advantage. Methods A randomized control trial study.Forty-one patients (41 eyes) with neovascular glaucoma were randomly divided into two groups, group A (20 eyes) was treated with iris and chamber angle neovascularization phtocoagulation and trabeculectomy combined with anterior retinal ciyotherapy (ARC) while group B (20 eyes) received cyclocryosurgery combined with anterior retinal cryotherapy (ARC) .The intraocular pressure (IOP) and conditions in the eye in one week were observed.Follow-up status of intraocular pressure and complication was one year.Results Intraocular pressure of group A was remarkable lower than group B one week after the operation, there was statistical significant difference (t=7.12, P<0.01) between two groups. Ophthalmalgia of group A was significant relieved, showing significant difference (χ2=7.15, P<0.01 ).In one year of postoperation, intraocular pressure of group A was controlled in normal range accounted for 90% (18/20) while group B occupied 49% (10/21), the difference was statistically significant (t=2.73, P<0.05). Iris neovascularization (INV) of two groups both decreased, but group A was better than group B, thus they had statistical differences (χ2=5.53, P<0.05).Conclusions Ms and chamber angle neovascularization phtocoagulation and trabeculectomy combined with anterior retinal cryotherapy (ARC) has more advantage in treatment of neovascular glaucoma.