Objective To study the effect of bilberry extract on binocular contrast sensitivity in children with amblyopia.Methods Collect monocular or binocular amblyopia patients 120 cases,who visited in our hospital from 2012 July to 2012 September,randomly divided into treatment group (60 cases) and control group (60 cases).The treatment group based on routine treatment of amblyopia on the use of bilberry extract for 3 months,the control group only routine treatment of amblyopia.After followed up for 3 months to observe the changes of eye best corrected visual acuity and contrast sensitivity.Results During the treatment,two groups amblyopic eye got different extent improvement in best corrected visual acuity and contrast sensitivity of the spatial frequency.While the treatment group was better than the control group,the difference was statistically significant (P ＜0.05).Both of the treatment group and the control group of amblyopic eye contrast sensitivity was improved,but no significant difference between the two groups (P ＞0.05); For the monocular amblyopia patients,the "healthy eye" got improvement in high spatial frequency contrast sensitivity in treatment group,a significant difference with the control group (P ＜0.05).Conclutions Use of bilberry extract had certain effect to improve the visual function of children with amblyopia,especially to a certain extent to improve the contrast sensitivity of the "healthy eye "of the monocular amblyopia children.