Objective To check up the consistency of theoretic frame and practical data of "main care-givers,empewerment measurement" as well as its feasibility. Methods Through wide paper re-searching, the original theory "self- dependence" of China which based on the "empowerment" theory from the west was built up. Then a theoretic measurement sheet was made of which the theoretic reliability and contest reliability were both checked through multiple procedures. Finally the result was screened and puri-fied into 64 items. In this study, 120 main care- givers of in- patients over 65 years old were taken as the objects, and a pre-test with the 64-itemsheet. Results Empowerment measurement reliability was 0.89, 9 factors were all confirmed at factor analysis, cumulative contribution rate was 56.3%. Conclusions "Mea-surement of main care- givers' empewerment" is available, highly reliable and capable of application.