Original Article
Huai qi huang granules for the treatment of children with mycoplasma pneumoniae pneumonia: a multi-center clinical study
Shan Lishen, Shang Yunxiao, Li Miao, Han Xiaohua, Cheng Huanji, Huang Yan, Dai Jicheng, Qu Shuqiang, Sun Jun, Bai Yan, Liu Changshan, Ren Shaomin, Li Yingchun, Sun Liping, Zou Yingxue, Xu Hao, Wu Xiuqing, Yan Hong, Chen Jing, Yao Li, Su Yanqi, Jia Chunmei, Shi Chenghua, Liu Jianhua, Zhang Zhongping, Wang Jun, Han Yuling, Wang Yanfen, Wang Yushui, Yang Guang
Published 2018-01-26
Cite as Int J Pediatr, 2018,45(1): 53-57,72. DOI: 10.3760/cma.j.issn.1673-4408.2018.01.014
Abstract
ObjectiveTo analyze the effects of Huai qi huang granules on children with mycoplasma pneumoniae pneumonia.
MethodsA randomized, multicenter parallel controlled clinical trial was carried out.A total of 3 000 cases of hospitalized children with mycoplasma pneumoniae pneumonia were selected.All of them were given treatment for mycoplasma pneumoniae pneumonia with macrolide antibiotics and symptomatic treatment.They were randomly divided into 2 groups: research group and control group.The children of research group were give oral Huai qi huang granules for three months.According to the classification of pneumonia, these two groups were divided into: lobar pneumonia research group, lobar pneumonia control group, lobular pneumonia research group, lobular pneumonia control group.The hospitalization duration of fever, length of hospital stay, the absorption area of lung inflammation and pneumonia severity sores were observed.The frequency of upper respiratory infections, bronchitis, pneumonia were observed in 3 months after discharge.
Results2 378 cases were investigated.The hospitalization duration of fever, length of hospital stay of research group were significantly shorter than that of in control group(P<0.001). The children with lobar pneumonia, 2 weeks after treatment, the absorption of consolidation of the lobar pneumonia research group is significantly better than lobar pneumonia control group(P<0.001). After two weeks treatment, the pneumonia scores of lobar pneumonia research group is lower than lobar pneumonia control group(P<0.05). Follow-up of 3 months after hospital discharge, frequency of upper respiratory infection and bronchitis of research group, were significantly lower than that of control.In addition, appetite increased significantly in research group than control(P<0.001). There are 21 cases with drug associated adverse reactions(mild diarrhea), including 12 cases of research group, 9 cases of control group, and there was no statistical significance(P>0.05).
ConclusionStandard treatment combined with oral Huai qi huang granules in the treatment of mycoplasma pneumoniae pneumonia, can significantly shorten hospitalization duration of fever, length of hospital stay and reduce the severity score of pneumonia.Three months oral Huai qi huang granules can significant reduce the frequency of respiratory infections and bronchitis, also can increase patients appetite, and be safe.
Key words:
Mycoplasma pneumoniae pneumonia; Huai qi huang granules; Children; Randomized controlled trial; Multicenter study
Contributor Information
Shan Lishen
Department of Pediatric Respiratory, Shengjing Hospital of China Medical University, Shenyang 110004, China
Shang Yunxiao
Li Miao
Han Xiaohua
Cheng Huanji
Huang Yan
Dai Jicheng
Qu Shuqiang
Sun Jun
Bai Yan
Liu Changshan
Ren Shaomin
Li Yingchun
Sun Liping
Zou Yingxue
Xu Hao
Wu Xiuqing
Yan Hong
Chen Jing
Yao Li
Su Yanqi
Jia Chunmei
Shi Chenghua
Liu Jianhua
Zhang Zhongping
Wang Jun
Han Yuling
Wang Yanfen
Wang Yushui
Yang Guang
