Original Article
The clinical study of budesonide combined with pulmonary surfactant to prevent bronchopulmonary dysplasia in premature infants
Su Jinzhen, Yang Yulan, Yang Lin, Ding Lu, Zhong Guichao, Liu Lan, Wu Benqing
Published 2019-01-26
Cite as Int J Pediatr, 2019,46(1): 61-65. DOI: 10.3760/cma.j.issn.1673-4408.2019.01.015
Abstract
ObjectiveTo investigate whether the therapy of combining budesonide with pulmonary surfactant, compared with only surfactant, has an effect on the incidence of bronchopulmonary dysplasia, mortality and other complications in preterm infants.
MethodsThe preterm infants in accordance with the inclusion criteria, who were born during from 12/2016 and 2/2018, were randomly divided into the combination treatment group (treated with the combination of budesonide and pulmonary surfactant)and control group(treated with only surfactant). Ninety eight preterm infants were enrolled this trial, 48 of whom are in budesonide group and 50 are in control group.The basic data were not have statistic significant between two groups except for birth weight(P>0.05). The incidence of bronchopulmonary dysplasia, the mortality and other complication of premature were compared.
ResultsThere was a statistic significance in the incidence of bronchopulmonary dysplasia between the budesonide group and control group(42% vs 66%, P<0.05); The severity of bronchopulmonary dysplasia and case fatality rate between two groups have no satistical difference.The complications of preterm infants in two groups also have no statistical difference apart from the incidence of PDA(15% vs 38%, P<0.05).
ConclusionBudesonide combined with pulmonary surfactant can reduce the incidence of bronchopulmonary dysplasia and does not increase mortality and the rate of other complications in preterm infants.
Key words:
budesonide; pulmonary surfactant; bronchopulmonary dysplasia; premature
Contributor Information
Su Jinzhen
Department of Neonatology, Shenzhen Hospital of University of Chinese Academy of Sciences, Shenzhen 518106, China (Su Jinzhen is working on the Department of Neonatology, Dongguan Maternal and Child Health Care Hospital, Dongguan 523000, China)
Yang Yulan
Department of Neonatology, Shenzhen People′s Hospital, Shenzhen 518020, China
Yang Lin
Department of Neonatology, Shenzhen People′s Hospital, Shenzhen 518020, China
Ding Lu
Department of Neonatology, Shenzhen People′s Hospital, Shenzhen 518020, China
Zhong Guichao
Department of Neonatology, Shenzhen People′s Hospital, Shenzhen 518020, China
Liu Lan
Department of Neonatology, Shenzhen People′s Hospital, Shenzhen 518020, China
Wu Benqing
Department of Neonatology, Shenzhen Hospital of University of Chinese Academy of Sciences, Shenzhen 518106, China
