Response gene to complement 32(RGC-32)as an important response gene to complement was widely expressed in a lot of tissues and organs and participated in many biological processes such as cell proliferation and differentiation, cell cycle regulation, inflammation, immune regulation, and tumor, etc.As a cell cycle regulator, RGC-32 affected the development of numerous diseases by regulating the cell cycle.In recent years, many studies have shown that RGC-32 may be involved in the renal tubular injury and repair, and its role in the renal tubular injury and repair may be related to its regulation of cell cycle especially the G2/M.This article will make a brief review on the progress of the mechanism of RGC-32 regulating the renal injury and repair.