Objective To study the effect of early nursing intervention on deep vein thrombosis of lower extremities after major orthopedic surgery.Methods The contrast method of historical review was used,304 patients were divided into control group and observation group;138 cases of control group were treated with conventional orthopedic nursing;166 cases of observation group were treated with basic prevention,physical prevention and drug prevention through the assessment,early identification of high-risk groups.The formation of two groups of clinical symptoms and signs of the relevant indicators were monitored,the incidence of DVT was observed.Results Leg swelling,pain and the incidence of DVT were compared between two groups,the difference was statistically significant(P ＜ 0.05).Conclusions There is a great role of early comprehensive intervention in prevention of the formation of DVT.