Polycystic ovary syndrome(PCOS) is a common female reproductive endocrine disease that is highly related with abnormal glucose and lipid metabolism.It has been recognized that insulin resistance (IR) and hyperinsulinemia are the important pathologic changes.In recent years,chronic subclinical inflammation in the pathogenesis of PCOS has been of concern.Chronic subclinical inflammation plays important rotes through the low level proinflammatory cytokines such as C reactive protein (CRP),interleukin 6 (IL-6),tumor necrosis factor alpha (TNF-or).Studies have shown that chronic subclinical inflammation may be the first cause of IR.The research of cytokines' changes in PCOS is of great significance to explore the pathogenesis of PCOS.