CXCL12-induced signalling pathway plays an important role in regulating the activation and recruitment of immunocytes,mobilization and homing of hematopoietic stem cells,neo-angiogenesis,embryogenesis,invasion and metastasis of tumor cells.Rencently,the regulation of CXCL12/CXCR4/CXCR7 axis in placental implantation and development has aroused considerable attention.Related studies suggest that CXCL12-induced signalling can not only regulate differentiation,proliferation and invasion of placental trophoblast cells,but also induce trophoblast directed migration into decidual stromal tissues and blood vessels,promote placental implantation,uteroplacental vascular remodeling,materno-fetal immune tolerance,which further maintains the progression of pregnancy.A better understanding of the mechanism of CXCL12/CXCR4/CXCR7 axis in the maintenance of trophoblast functions may give insight into the process of placental implantation,hope fully offering a novel treatment strategy for trophoblast cells dysfunction-related diseases.