Healthy People, Healthy Sociey
The mechanisms and related factors of poor immune reconstitution in HIV infected individuals
Zhao Yilin, Jiang Yue, Ling Hong, Zhuang Min
Published 2020-11-05
Cite as Int J Immunol, 2020,43(06): 603-609. DOI: 10.3760/cma.j.issn.1673-4394.2020.06.001
Abstract
After antiretroviral therapy, 9% to 45% of HIV infected individuals have achieved virological suppression, but CD4+ T cell counts did not recover. These people are called as HIV infected individuals with poor immune reconstitution (PIR) or immune non-responders (INRs). INRs have a higher risk of developing AIDS and non-AIDS, and have a lower life expectancy, that resulted in difficulty for treatment. In this review, we aim to discuss the factors related to INR and its relationship with disease progression. Exploring mechanisms of INR development will provide ideas for evaluating disease prognosis and optimization of the treatment plans.
Key words:
HIV; Antiretroviral therapy; Poor immune reconstitution; Immunological non-responders; CD4+ T cell
Contributor Information
Zhao Yilin
Department of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, Heilongjiang Provincial, Key Laboratory for Infection and Immunity, Key Laboratory of Pathogen Biology in Heilongjiang Provincial Education Institute, Harbin 150081, China
Jiang Yue
Department of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, Heilongjiang Provincial, Key Laboratory for Infection and Immunity, Key Laboratory of Pathogen Biology in Heilongjiang Provincial Education Institute, Harbin 150081, China
Ling Hong
Department of Immunology, Harbin Medical University, Harbin 150081, China
Zhuang Min
Department of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, Heilongjiang Provincial, Key Laboratory for Infection and Immunity, Key Laboratory of Pathogen Biology in Heilongjiang Provincial Education Institute, Harbin 150081, China
