Association of the polymorphism of HLA-DRB1 gene with susceptibility to tuberculosis in a Xinjiang Han population
LIU Yu-cai, HE Peng, WANG Xi, WU Fang, WANG Ping, ZHANG Le, ZHANG Wan-jiang
Published 2010-07-15
Cite as Int J Genet, 2010,33(04): 193-197. DOI: 10.3760/cma.j.issn.1673-4386.2010.04.001
Abstract
Objectives To investigate the association between the polymorphism of HLA-DRB1 gene and susceptibility to tuberculosis in Xinjiang Han population. Methods 228 patients with tuberculosis in Tacheng and Shihezi of Xinjiang province were tested for the HLA-DRBl gene using the polymerase chain reaction with sequence-specific primer (PCR-SSP) technique, and the results were compared with those of 231 healthy individuals. Gene frequencies (GFs) were calculated and compared. Using Chi-square test to analysis the association between alleles and tuberculosis. Results The frequency of HLA-DRBl * 12 is 9.92% in the group with tuberculosis disease, and it is significantly higher than 2. 85% in the group of contort(χ2 = 18. 76, Pc<0.01). The freuqency of HLA-DRBl * 11 in tuberculosis was significantly decreased (χ2 =9.513, Pc <0. 05). Conclusion The results showed that HLA-DRBl * 12 was probably susceptible gene in tuberculosis for Xinjiang Han population, and HLA-DRBl * 11 may be a protective gene for Xinjiang Han population.
Key words:
Tuberculosis; Genotype; HLA-DRBl gene; PCR-SSP
Contributor Information
LIU Yu-cai
Department of Immunology, Medical School of Shihezi University/Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University, Shihezi 832002, China
HE Peng
Department of Immunology, Medical School of Shihezi University/Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University, Shihezi 832002, China
WANG Xi
Department of Immunology, Medical School of Shihezi University/Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University, Shihezi 832002, China
WU Fang
Department of Immunology, Medical School of Shihezi University/Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University, Shihezi 832002, China
WANG Ping
Department of Immunology, Medical School of Shihezi University/Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University, Shihezi 832002, China
ZHANG Le
Department of Immunology, Medical School of Shihezi University/Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University, Shihezi 832002, China
ZHANG Wan-jiang
Department of Immunology, Medical School of Shihezi University/Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University, Shihezi 832002, China
