Colorectal cancer (CRC) is one of the most common types of cancer in the world, and the clear mechanism of its occurrence and development has not been fully understood yet. In recent years, with the development of genome-wide and transcriptome sequencing technologies, long-chain non-coding RNAs (lncRNA) have received more and more attention. A large number of studies have shown that lncRNA is implicated in successive steps in cancer development. CRC-associated lncRNAs have been shown to regulate genes through a variety of mechanisms, including epigenetic modifications, lncRNA-miRNA and lncRNA-protein interactions, and their role as miRNA precursors. Since some lncRNAs can be detected in human body fluids and have good specificity and sensitivity, they have been considered as new potential biomarkers for CRC diagnosis and prognosis as well as predictive response to treatment. In this review, we discuss the recent findings of lncRNA in CRC and their application in clinical diagnosis, prognosis, and treatment.

Long noncoding RNA; Colorectal cancer; Tumor development