Original Article
Observation of prolactin and estradiol levels in lactating women in different iodine nutrition areas
Baiming Jin, Siyuan Wan, Hongmei Shen, Lixiang Liu, Fangang Meng, Xiaoye Zhang
Published 2019-05-20
Cite as Chin J Endemiol, 2019, 38(5): 381-384. DOI: 10.3760/cma.j.issn.2095-4255.2019.05.008
Abstract
ObjectiveTo observe prolactin (PRL) and estradiol (E2) levels in lactating women in different iodine nutrition areas.
MethodsAccording to the recent national water-borne high iodine area survey and the monitoring results of iodine deficiency disorders, the following places were selected, including Nankang, Xinggang and Yingpan towns of Beihai City, Guangxi (water iodine≤10 μg/L, low iodine areas), Yangcheng Township and Jiajiazhuang Township of Fenyang City, Shanxi (water iodine 50-100 μg/L, adaptive iodine areas), Pingyao County and Jicun Town of Fenyang City, Shanxi (water iodine ≥300 μg/L, high iodine areas), and urinary and blood samples were collected in lactating women (n=100, 97, 123) from the three regions. The urinary iodine concentration was tested by arsenic cerium catalytic spectrophotometry. Serum levels of PRL and E2 were determined by chemiluminescence immunoassay.
ResultsThe urinary iodine medians of lactating women were 51.42, 283.62, 842.31 μg/L, respectively, in the three regions, the difference between the regions was statistically significant (χ2=241.09, P < 0.05); the iodine levels of lactating women in low iodine areas, adaptive iodine areas and high iodine areas were in the state of iodine deficiency (< 100 μg/L), sufficient or adequate (200-299 μg/L) and iodine excess status (≥300 μg/L), respectively. Serum PRL and E2 levels of lactating women in the three types of areas were 38.81, 20.98, 16.41 μg/L and 29.57, 43.70, 45.51 ng/L, respectively. The differences between the regions were statistically significant (χ2=41.54, 24.03, P < 0.05).
ConclusionWith the increase of iodine nutrition level, PRL in lactating women has presented a gradually decreasing trend, E2 is increased.
Key words:
Iodine; Lactating women; Prolactin; Estradiol
Contributor Information
Baiming Jin
Department of Preventive Medicine, School of Public Health, Qiqihar Medical College, Qiqihar 161006, China
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
Siyuan Wan
Department of Preventive Medicine, School of Public Health, Qiqihar Medical College, Qiqihar 161006, China
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
Hongmei Shen
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
Lixiang Liu
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
Fangang Meng
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
Xiaoye Zhang
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
