Clinical Medicine
Clinical study on the relationship between hyperthyroidism and vascular endothelial injury
Chang Manli, Yu Tianlong, Jing Miao, Gao Yunyan, Liu Chang, Liu Lanchun, Su Xiaohui, Jia Haihan, Liu Peng
Published 2019-11-20
Cite as Chin J Endemiol, 2019,38(11): 918-921. DOI: 10.3760/cma.j.issn.2095-4255.2019.11.013
Abstract
ObjectiveTo observe the relationship between hyperthyroidism and vascular endothelial injury.
MethodsFrom 2016 to 2017, data of 60 patients with simple hyperthyroidism, autoimmune thyroid disease, cardiovascular and cerebrovascular diseases were collected from the Second Affiliated Hospital of Harbin Medical University. And 60 healthy subjects were enrolled in the same period as a healthycontrol group. The enzyme-linked immunosorbent assay (ELISA) was used to detect the content of vascular endothelial injury markers (vWF), thrombomodulin (TM), endothelin-1 (ET-1), P-selectin in serum of all subjects, as well as the serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroglobulin antibody (TgAb), and anti-thyroid peroxidase antibody (TPOAb) in patients with cardiovascular and cerebrovascular diseases levels. The correlation analysis of vascular endothelial injury in the simple hyperthyroidism group, autoimmune thyroid disease group, cardiovascular and cerebrovascular diseases group and healthy control group was conducted.
ResultsThere were statistically significant differences between the healthy control group, the simple hyperthyroidism group, the autoimmune thyroid disease group and the cardiovascular and cerebrovascular diseases group in the serum levels of vWF, TM, ET-1 and P-selectin, respectively(F = 6.56, 9.19, 7.88, 12.45, P < 0.05), and the simple hyperthyroidism group, autoimmune thyroid disease group, cardiovascular and cerebrovascular diseases group were significantly higher than the healthy control group (P < 0.05). Correlation analysis showed that the vascular endothelial injury in the patients with simple hyperthyroidism, autoimmune thyroid disease, and cardiovascular and cerebrovascular diseases groups was statistically significantly different compared with the healthy control group, respectively(χ2 = 5.08, 5.08, 8.16, P < 0.05); the risk of vascular endothelial injury in each diseased group was 2.37, 2.37, and 3.07 times higher than that of the healthy control group, respectively. The abnormal rates of TSH, FT3, FT4, TgAb and TPOAb in patients with cardiovascular and cerebrovascular diseases were 18.33% (11/60), 15.00% (9/60), 15.00% (9/60), 10.00% (6/60) and 11.7% (7/60), respectively.
ConclusionSimple hyperthyroidism and autoimmune thyroid disease are risk factors of vascular endothelial injury.
Key words:
Thyroid function; Endothelial injury; Cardiovascular and cerebrovascular diseases
Contributor Information
Chang Manli
Clinical laboratory, The Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China
Yu Tianlong
Institute of Endemic Disease Disorders, Center for Disease Control in Harbin, Harbin 150081, China
Jing Miao
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China
Gao Yunyan
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China
Liu Chang
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China
Liu Lanchun
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China
Su Xiaohui
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China
Jia Haihan
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China
Liu Peng
Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China
