Iodine nutrition status and abnormal thyroid function of early pregnant women
Zhu Sujuan, Xu Weimin, Jin Xingyi, Huo Liangliang
Published 2014-07-25
Cite as Chin J Endocrinol Metab, 2014,30(07): 553-557. DOI: 10.3760/cma.j.issn.1000-6699.2014.07.003
Abstract
Objective To investigate the prevalence of thyroid disease in early pregnancy women of Hangzhou,and further to discuss the necessity of screening thyroid function in early pregnant women.Methods From March to October 2013,1 165 cases of women in the center of community health service (or health) for routine prenatal care during early pregnancy were used as research subjects.Household salt,fasting morning urine and serum samples were collected.The salt iodine level was measured by direct titration of sodium thiosulfate.The urinary iodine level was measured by arsenic-cerium contact process method.The levels of serum TSH,FT4,and thyroid peroxidase antibody (TPOAb) were measured by chemiluminescence method.Results The median of urinary iodine of the early pregnancy women was 135.2 μg/L,and only 26.7% of early pregnancy women' s iodine-nutrition status were optimal.These were no significant difference in median urinary iodine as well as the frequency distribution between urban and suburban(P>0.05).The abnormal rates of TSH and FT4 in early pregnancy women with negative TPOAb were 6.8% (71/1 039) and 8.9% (92/1 039),and the abnormal rates of TSH and FT4 in suburban areas were higher than those in urban areas(P=0.035,P =0.001).The prevalences of hypothyroidism,subclinical hypothyroidism,and hypothyroxinemia in early pregnant women of Hangzhou were 0.3% (3/1 165),2.0% (23/1 165),and 4.8% (56/1 165) respectively,and the prevalence of hypothyroxinemia in suburban areas was significantly higher than that in urban areas (6.1% vs 3.5%,P =0.040).The positive rate of TPOAb was 9.9% (114/1 153).The early pregnant women with positive TPOAb have an increased risk of thyroid dysfunction,the ratio of TSH over the reference values was significantly higher than that in the negative group and more prone to subclinical hypothyroidism (OR =3.34,95% CI 1.29-8.65).Conclusion The early pregnant women in rural areas or with positive TPOAb have an increased risk of abnormal thyroid function,thyroid function and iodine nutrition screening or monitoring should be highlighted.
Key words:
Early pregnancy; Iodine nutrition; Thyroid function
Contributor Information
Zhu Sujuan
Center for Disease Control and Prevention of Hangzhou , Hangzhou 310021, China
Xu Weimin
Center for Disease Control and Prevention of Hangzhou , Hangzhou 310021, China
Jin Xingyi
Center for Disease Control and Prevention of Hangzhou , Hangzhou 310021, China
Huo Liangliang
Center for Disease Control and Prevention of Hangzhou , Hangzhou 310021, China