Adrenal Disease
Characteristics of abdominal fat distribution in patients with primary aldosteronism
Zhu Beibei, Wu Yan, Ren Gaofei, Zhang Pengyu, Guo Xiaoqing, Gao Yue, Xing Jingjing, Xiong Huiqin, Li Xialian
Published 2019-10-25
Cite as Chin J Endocrinol Metab, 2019,35(10): 834-837. DOI: 10.3760/cma.j.issn.1000-6699.2019.10.004
Abstract
ObjectiveTo compare the abdominal fat distribution in patients with primary aldosteronism (PA) and essential hypertension (EH), and to analyze the correlation between abdominal fat area and indexes such as glycolipid metabolism and insulin resistance.
MethodsForty-five PA and 55 EH patients were collected from inpatients in the First Affiliated Hospital of Zhengzhou University for suspicious secondary hypertension, from September 2016 to February 2019. All patients received quantitative computed tomography to measure the total abdominal fat area (TFA), visceral fat area (VFA), and subcutaneous fat area (SFA) when receiving adrenal CT detection. Visceral obesity was defined as VFA≥130 cm2. The percentage of visceral fat area in total abdominal fat area (V%=VFA/TFA), the ratio of visceral fat area to subcutaneous fat area (V/S=VFA/SFA) and the percentage of visceral obesity were calculated.
ResultsTFA and VFA in EH group were higher than those in PA group matched by age, gender, and body mass index (BMI, all P<0.01), and there were no statistically significant differences in SFA, V%, V/S, and the percentage of visceral obesity between the two groups. In PA group, TFA and VFA were positively correlated with homeostasis model assessment of insulin resistance index (P<0.01), TFA was positively correlated with triglycerides (TG) and low density lipoprotein-cholesterol, while SFA was positively correlated with TG (all P<0.05).
ConclusionCompared with EH patients matched by age, gender, and BMI, TFA and VFA in PA patients are lower. Abdominal fat area is associated with insulin resistance and blood lipids in PA patients, while VFA exerts a greater effect on insulin resistance than that of TFA and SFA.
Key words:
Primary aldosteronism; Abdominal fat area; Insulin resistance; Quantitative computed tomography
Contributor Information
Zhu Beibei
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Wu Yan
Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Ren Gaofei
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Zhang Pengyu
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Guo Xiaoqing
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Gao Yue
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Xing Jingjing
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Xiong Huiqin
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Li Xialian
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
