Clinical Original Article
Association between atherogenic index of plasma and renal function impairment in patients with gout
Ruirui Song, Kahaer Mayna, Bei Zhang, Xiaobo Zhang, Ying Lu, Ge Tian, Shanshan Yang, Yuping Sun
Published 2019-12-25
Cite as Chin J Endocrinol Metab, 2019, 35(12): 1043-1049. DOI: 10.3760/cma.j.issn.1000-6699.2019.12.009
Abstract
ObjectiveTo study the relationship between atherogenic index of plasma (AIP)and renal impairment in male patients with gout.
MethodsA retrospective analysis of 821 male subjects was conducted to measure the relevant biochemical indicators and to calculate the AIP, endogenous creatinine-clearance rate (Ccr), and estimated glomerular filtration rate (eGFR). EpiData 3.1 software was used for data entry, SPSS21.0 was used for statistical analysis, and GraphPad Prism 6.0 software was used for charts.
ResultsCompared with control group, AIP, serum uric acid, triglyceride in gout group were significantly higher (all P<0.01), while eGFR and high density lipoprotein-cholesterol were significantly lower (both P<0.05). The composition ratio of renal function impairment in gout group was significantly higher (P<0.01). With the increase of AIP level, eGFR level decreased and serum creatinine level increased, but the overall difference was not statistically significant (P>0.05), while Ccr and serum uric acid levels gradually increased (P<0.05). Logistic regression analysis after adjusting for various confounding factors showed that AIP, triglyceride, and serum uric acid were risk factors for renal function damage in patients with gout (P<0.05), the relevant risk were 7.030, 1.291, 1.004 respectively. After adjusting confounding factors, the associations between triglyceride, serum uric acid and renal function injury risk changed little, while AIP showed more evident, the OR value increased from 2.629 to 6.265 and 7.030.
Conclusions(1)AIP is closely related to the renal function damage of patients with gout. After adjusting various confounding factors, AIP can better reflect the renal function damage than other indicators, which is of great significance to predict the renal function damage of patients with gout. (2)That patients with gout with high uric acid level may suffer from renal atherosclerosis and have a higher risk of renal impairment. (3)Dynamic observation of AIP in gout patients is helpful for early identification of the risk of renal failure in such patients.
Key words:
Gout; Renal damage; Atherogenic index of plasma; Confounding factors
Contributor Information
Ruirui Song
School of Basic Medicine, Xinjiang Medical University, Urumqi 830011
Kahaer Mayna
School of Basic Medicine, Xinjiang Medical University, Urumqi 830011
Bei Zhang
School of Basic Medicine, Xinjiang Medical University, Urumqi 830011
Xiaobo Zhang
School of Basic Medicine, Xinjiang Medical University, Urumqi 830011
Ying Lu
Department of Respiration, the First Hospital Affiliated to Xinjiang Medical University, Urumqi 830011
Ge Tian
Central Laboratory, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi 830011
Shanshan Yang
Department of Clinical Laboratory, the Fifth Hospital Affiliated to Xinjiang Medical University, Urumqi 830011
Yuping Sun
School of Basic Medicine, Xinjiang Medical University, Urumqi 830011
