Clinical Original Article
Relationship between life events and serum uric acid in patients with hyperuricemia
Ma Yiwen, Chen Haibing
Published 2020-02-25
Cite as Chin J Endocrinol Metab, 2020,36(02): 127-132. DOI: 10.3760/cma.j.issn.1000-6699.2020.02.007
Abstract
ObjectiveTo investigate the relationship between psychological stress related factors in life events and serum uric acid levels in patients with hyperuricemia.
MethodsThe life events scale was used to qualitatively and quantitatively analyze the mental stimulation of 60 hyperuricemia patients. The laboratory analysis, as well as correlation analysis and multivariate regression analysis, were used to compare the general data and biochemical indicators of patients under different pressures.
ResultsPatients with a total score of 20 or less on the life event scale were included in the low-pressure group, and the total score greater than 20 points in the high-pressure group. The highest frequency of positive and negative life events were outstanding achievement and stress in work and study. The frequency of gout attacks and cholesterol, triglyceride, serum creatinine, serum uric acid, and cortisol levels in the high-pressure group were significantly higher than those in the low-pressure group (P<0.05). The positive life event stimulation was positively correlated with cholesterol and triglyceride, and the negative life event stimulation was positively correlated with uric acid. In the multivariate linear regression analysis with serum uric acid as the dependent variable, the frequency of gout attacks and the stress group finally entered the regression model in the last year. The regression model had statistical significance F(2, 54)=27.765(P<0.01), adjusted R2=0.522.
ConclusionsIn patients with hyperuricemia who are greatly stimulated in family life and work in life events, mental stress is related with elevated levels of cholesterol, triglycerides and serum uric acid. Elevated triglycerides and cholesterol are related to positive life events, and the rise of blood uric acid is related to negative life events. For patients with hyperuricemia, high-stress and frequent gouts are associated with higher levels of serum uric acid.
Key words:
Hyperuricemia; Life events; Psychological stress; Gout
Contributor Information
Ma Yiwen
Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People′s Hospital, Shanghai 200233, China
Chen Haibing
Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People′s Hospital, Shanghai 200233, China
