Original Article
Epidemiological and clinical features of human immunodeficiency virus/hepatitis B virus co-infected patients
Simin Huang, Weiping Cai, Fengyu Hu, Baolin Liao, Yun Lan, Youpeng Chen, Xiaoping Tang
Published 2015-07-15
Cite as Chin J Infect Dis, 2015, 33(7): 391-395. DOI: 10.3760/cma.j.issn.1000-6680.2015.07.004
Abstract
ObjectiveTo investigate the epidemiologic and clinical features of human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infected patients.
MethodsPatients who confirmed with HIV infection and received highly active anti-retroviral therapy (HAART) at Guangzhou Eighth People's Hospital were enrolled. HIV/HBV co-infected patients and HIV mono-infected patients were screened and their epidemiological and clinical features were analyzed before HAART. Comparison of the levels of alanine transaminase (ALT), aspartate transaminase (AST), CD4+ T lymphocyte and HIV RNA between the two groups were conducted. The data were statistically analyzed by chi-square test and nonparametric test.
ResultsOne hundred and sixty-five out of 1 218(13.5%) patients were hepatitis B surface antigen positive. The median ALT and AST levels of HIV mono-infected patients were 29 U/L and 34 U/L respectively, which were both higher than HIV/HBV co-infected patients (22 U/L and 25 U/L, respectively) (Z=-4.270 and Z=-5.780, respectively, both P=0.000). The median CD4+ T lymphocyte count of HIV/HBV co-infected patients was significantly lower than that of HIV mono-infected patients (Z=-2.980, P=0.003). The CD4+ T lymphocyte count was lower in hepatitis B e antigen (HBeAg) positive patients than HBeAg negative patients (Z=-2.660, P=0.008). The median CD4+ T lymphocyte count in patients with HBV DNA≥5 lg copy/mL was significantly lower than those with HBV DNA<5 lg copy/mL (Z=-2.311, P=0.021). The proportions of positive HBV DNA, HBV DNA≥5 lg copy/mL, abnormal ALT and AST in 54 patiens with CD4+ T lymphocyte counts<50/μL were 81.5%, 66.7%, 44.4% and 53.7%, respectively. All were significantly higher than patients with CD4+ T lymphocyte count≥50/μL(χ2=6.159, P=0.046 ; χ2=6.618, P=0.037 ; χ2=7.144, P=0.028 and χ2=9.586, P=0.008, respectively).
ConclusionsThe prevalence of HBV/HIV co-infection is high in this study. The CD4+ T lymphocyte counts in HIV/HBV co-infected patients are lower, especially in patients with HBeAg positive and high HBV DNA level. The CD4+ T lymphocyte counts are associated with HBV DNA replication levels.
Key words:
HIV; Hepatitis B virus; Co-infection; Epidemiology; Clinical features
Contributor Information
Simin Huang
Department of Medicine, The First Affiliated Hospital of Ji'nan University, Guangzhou 510630, China
Weiping Cai
Fengyu Hu
Baolin Liao
Yun Lan
Youpeng Chen
Xiaoping Tang
